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Naphthalimide-based macrophage nucleus imaging probes

AuthorsFueyo-González, Francisco; Fernández-Gutiérrez, Mar ; Orte, Angel; González-Vera, Juan A. ; García-Puentes, Diego; Herranz, Rosario
KeywordsFluorescence probes
Naphthalimide derivatives
Quinolimide derivatives
Macrophage imaging probes
DNA intercalants
Issue Date15-Aug-2020
CitationEuropean Journal of Medicinal Chemistry 200 (2020) 112407
AbstractThe photophysical properties of naphthalimide-based fluorophores can be easily tuned by chemical manipulation of the substituents on that privileged scaffold. Replacement of a OMe group at position 6 in 2-(hydroxyl)ethyl-naphthalimide derivatives by diverse amines, including 2-(hydroxyl)ethylamine, trans-(4-acetamido)cyclohexylamine and azetidine increases the solvatochromic (ICT) character, while this replacement in 2-(dimethylamino)ethyl-naphthalimide analogues (PET fluorophores) decrease their solvent polarity sensitivity or even reversed them to solvatochromic fluorophores. These fluorophores resulted macrophage nucleus imaging probes, which bind DNA as intercalants and showed low cytotoxicity in human cancer cells
Publisher version (URL)https://doi.org/10.1016/j.ejmech.2020.112407
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