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Título

Bovine endometrial MSC: mesenchymal to epithelial transition during luteolysis and tropism to implantation niche for immunomodulation

AutorCalle, Alexandra; López-Martín, Soraya; Monguió-Tortajada, Marta; Enric Borrás, Francesc; Yáñez-Mó, María; Ramírez, Miguel Ángel
Palabras claveEndometrial mesenchymal stem cells
Embryo implantation
Inflammation
Cell migration
Fecha de publicación2019
CitaciónStem Cell Research and Therapy 10: 23 (2019)
ResumenBackground: The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood. The aim of this study was to isolate, immortalize and characterize bovine endometrial mesenchymal stem cell (eMSC) lines from different oestrous cycle stages (embryo in the oviduct, embryo in the uterus or absence of embryo) and examine their migratory and immunomodulatory properties in an inflammatory or implantation-like environment, as well as possible changes in cell transdifferentiation.
Versión del editorhttp://dx.doi.org/10.1186/s13287-018-1129-1
URIhttp://hdl.handle.net/10261/213990
DOI10.1186/s13287-018-1129-1
Identificadoresdoi: 10.1186/s13287-018-1129-1
issn: 1757-6512
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