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Bovine endometrial MSC: mesenchymal to epithelial transition during luteolysis and tropism to implantation niche for immunomodulation

AuthorsCalle, Alexandra; López-Martín, Soraya; Monguió-Tortajada, Marta; Enric Borrás, Francesc; Yáñez-Mó, María; Ramírez, Miguel A.
KeywordsEndometrial mesenchymal stem cells
Embryo implantation
Cell migration
Issue Date2019
CitationStem Cell Research and Therapy 10: 23 (2019)
AbstractBackground: The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood. The aim of this study was to isolate, immortalize and characterize bovine endometrial mesenchymal stem cell (eMSC) lines from different oestrous cycle stages (embryo in the oviduct, embryo in the uterus or absence of embryo) and examine their migratory and immunomodulatory properties in an inflammatory or implantation-like environment, as well as possible changes in cell transdifferentiation.
Publisher version (URL)http://dx.doi.org/10.1186/s13287-018-1129-1
Identifiersdoi: 10.1186/s13287-018-1129-1
issn: 1757-6512
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