English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/213972
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Formulation of Direct Compression Zidovudine Tablets to Correlate the SeDeM Diagram Expert System and the Rotary Press Simulator Styl’ONE Results

AuthorsNofrerias, I.; Nardi, A. ; Suñé-Pou, Marc; Suñé-Negre, J.M.; García-Montoya, E.; Pérez-Lozano, P.; Miñarro, M.; Bataille, B.; Ticó, J.R.
Issue Date2020
PublisherAmerican Association of Pharmaceutical Scientists
CitationAAPS PharmSciTech 21 (2020)
AbstractThe SeDeM diagram expert system has been applied to study Zidovudine and some excipients. From the obtained diagrams, a pharmaceutical formula has been designed. SeDeM diagram ascertains the critical parameters that are suitable for a direct compression. The formula is compressed using a rotary tablet press simulator which emulates rotary tablet press’ compression profiles. From these compressions, we study the formula behavior under different industrial production conditions but saving a huge amount of material. The study is done at different compression forces and compression speeds and taking into account the influence of the pre-compression force. The differences observed between the compression profiles are hereby described. The results indicate that the formulation is able to be compressed adequately with the emulated compression profiles and no differences are observed between the final products. Therefore, we can assure that the SeDeM diagram expert system is accurate and robust. Moreover, its results are comparable with the compression results in a rotary tablet press, which has never been described in the pharmaceutical literature before. From the obtained results, it is possible to select the best rotary press to scale-up this formulation.
Publisher version (URL)http://dx.doi.org/10.1208/s12249-019-1542-5
Identifiersdoi: 10.1208/s12249-019-1542-5
e-issn: 1530-9932
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.