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Mediterranean alcohol-drinking pattern, low to moderate alcohol intake and risk of atrial fibrillation in the PREDIMED study

AuthorsBazal, P.; Gea, A.; Martínez-González, Miguel Ángel; Salas-Salvadó, Jordi; Asensio, Eva M.; Muñoz-Bravo, C.; Fiol, Miquel; Muñoz, Miguel Ángel; Lapetra, Jose; Serra-Majem, Lluis; Pintó, Xavier; González, José I.; Becerra-Tomás, Nerea; Becerra-Tomás, Nerea; Ros, Emilio; Alonso-Gómez, Ángel M.; Ruiz-Canela, Miguel
Atrial fibrillation
Red wine
Issue DateJul-2019
CitationNutrition, Metabolism and Cardiovascular Diseases 29(7): 676-683 (2019)
Abstract[Background and aims] There is ongoing controversy about the effect of a low to moderate alcohol consumption on atrial fibrillation (AF). Our aim is to assess the association between adherence to a Mediterranean alcohol drinking pattern and AF incidence.
[Methods and results] A total 6527 out of the 7447 participants in the PREDIMED trial met our inclusion criteria. A validated frequency food questionnaire was used to measure alcohol consumption. Participants were classified as non-drinkers, Mediterranean alcohol drinking pattern (MADP) (10–30 g/d in men and 5–15 g/day in women, preferably red wine consumption with low spirits consumption), low-moderate drinking (<30 g/day men y and < 15 g/day women), and heavy drinking. We performed multivariable Cox regression models to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) of incident AF according to alcohol drinking patterns. After a mean follow up of 4.4 years, 241 new incident AF cases were confirmed. Alcohol consumption was not associated to AF incidence among low-moderate drinkers (HR: 0.96; 95%CI: 0.67–1.37), adherents to MADP (HR: 1.15 95%CI: 0.75–1.75), or heavy drinkers (HR: 0.92; 95%CI: 0.53–1.58), compared with non-drinkers.
[Conclusions] In a high cardiovascular risk adult population, a Mediterranean alcohol consumption pattern (low to moderate red wine consumption) was not associated with an increased incidence of AF.
[Clinical trials] URL: http://www.controlled-trials.com. Unique identifier: ISRCTN35739639.
Publisher version (URL)http://dx.doi.org/10.1016/j.numecd.2019.03.007
Identifiersdoi: 10.1016/j.numecd.2019.03.007
issn: 0939-4753
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