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dc.contributor.authorGarcía-Villén, Fátimaes_ES
dc.contributor.authorFaccendini, Angelaes_ES
dc.contributor.authorMiele, Dalilaes_ES
dc.contributor.authorRuggeri, Marcoes_ES
dc.contributor.authorSánchez Espejo, Ritaes_ES
dc.contributor.authorBorrego Sánchez, Anaes_ES
dc.contributor.authorCerezo, Pilares_ES
dc.contributor.authorRossi, Silviaes_ES
dc.contributor.authorViseras, Césares_ES
dc.contributor.authorSandri, Giuseppinaes_ES
dc.date.accessioned2020-06-08T09:50:04Z-
dc.date.available2020-06-08T09:50:04Z-
dc.date.issued2020-05-21-
dc.identifier.citationPharmaceutics 12(5): 467 (2020)es_ES
dc.identifier.issn1999-4923-
dc.identifier.urihttp://hdl.handle.net/10261/213693-
dc.description.abstractBackground: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.es_ES
dc.description.sponsorshipThis research was funded by Ministerio de Ciencia e Innovación, CGL2016–80833-R; Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía, P18-RT-3786 and Ministerio de Educación, Cultura y Deporte, FPU15/01577.es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institutees_ES
dc.relationMINECO/ICTI2013-2016/CGL2016-80833-Res_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectSepiolitees_ES
dc.subjectPalygorskitees_ES
dc.subjectSpring wateres_ES
dc.subjectHydrogeles_ES
dc.subjectFibroblastes_ES
dc.subjectBiocompatibilityes_ES
dc.subjectWound healinges_ES
dc.titleWound Healing Activity of Nanoclay/Spring Water Hydrogelses_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.3390/pharmaceutics12050467-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/pharmaceutics12050467es_ES
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003176es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.contributor.orcidSánchez Espejo, Rita [0000-0001-6525-5723]es_ES
dc.contributor.orcidViseras, César [0000-0002-2219-3566]es_ES
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