English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/213693
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Wound Healing Activity of Nanoclay/Spring Water Hydrogels

AuthorsGarcía-Villén, Fátima; Faccendini, Angela; Miele, Dalila; Ruggeri, Marco; Sánchez Espejo, Rita; Borrego Sánchez, Ana ; Cerezo, Pilar; Rossi, Silvia; Viseras, César; Sandri, Giuseppina
Spring water
Wound healing
Issue Date21-May-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationPharmaceutics 12(5): 467 (2020)
AbstractBackground: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.
Publisher version (URL)https://doi.org/10.3390/pharmaceutics12050467
Appears in Collections:(IACT) Artículos
Files in This Item:
File Description SizeFormat 
CViseras_Pharmaceutics12_467.pdfArtículo principal5,38 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.