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Title

Association of dietary components with dyslipidemia and low-grade inflammation biomarkers in adults with heterozygous familial hypercholesterolemia from different countries

AuthorsAntoniazzi, Luiza; Arroyo-Olivares, Raquel; Bittencourt, Marcio S.; Teruo Tada, Mauricio; Lima, Isabella; Jannes, Cinthia E.; Krieger, Jose E.; Pereira, Alexandre C.; Quintana-Navarro, Gracia; Muñiz-Grijalvo, Ovidio; Diaz-Diaz, Jose Luis; Zambón, Daniel; Mata, Pedro; Santos, Raul D.
KeywordsBiomarkers
Dyslipidaemias
Issue Date2019
PublisherSpringer Nature
CitationEuropean Journal of Clinical Nutrition 73: 1622-1625 (2019)
AbstractThe association of components of a low saturated fat (SFA) and of a Mediterranean diet was tested with atherosclerosis biomarkers in 190 familial hypercholesterolemia adults (FH) from Brazil (BR) and Spain (SP). Median blood LDL-C, Apolipoprotein B (apoB), and C reactive protein (hs-CRP) concentrations were higher in BR than in SP: 179.0 vs.161 mg/dL; 141 vs. 103 mg/dL; and 1.6 vs. 0.8 mg/L respectively (all p < 0.001). In BR there was lower median total fat (22.3 vs. 38.3%) and SFA (8.1 vs. 12.5%) but higher cholesterol (283.3 mg vs.188.9 mg) and carbohydrate (57.1 vs. 42.5%) consumption (all p < 0.001). Inverse associations were encountered between fibers, mono, and polyunsaturated fats and their ratios to SFA with LDL-C and ApoB (all p < 0.001). There was a direct association respectively of cholesterol with lipid biomarkers and of carbohydrates and trans-fatty acids with hs-CRP while other fats showed inverse relations with the latter (p < 0.001).
Publisher version (URL)http://dx.doi.org/10.1038/s41430-019-0529-3
URIhttp://hdl.handle.net/10261/213409
DOI10.1038/s41430-019-0529-3
ISSN0954-3007
E-ISSN1476-5640
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