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Title

Self-Assembly of Okadaic Acid as a Pathway to the Cell

AuthorsHernández Daranas, Antonio ; Cruz, Patricia G.; Hernández Creus, Alberto; Norte, Manuel; Fernández, José J.
KeywordsPotassium
Gold
Ions
Membranes
Scanning tunneling microscopy
Issue Date15-Sep-2007
PublisherAmerican Chemical Society
CitationOrganic Letters 9(21): 4191–4194 (2007)
AbstractThe polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of many essential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understand the mechanism of toxin transport across model membranes.
Publisher version (URL)https://doi.org/10.1021/ol701687m
URIhttp://hdl.handle.net/10261/213381
DOI10.1021/ol701687m
ISSN1523-7060
E-ISSN1523-7052
Appears in Collections:(IPNA) Artículos
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