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Proteomic Profile Associated With Loss of Spontaneous Human Immunodeficiency Virus Type 1 Elite Control

AuthorsRodríguez-Gallego, Esther; Tarancón-Díez, Laura; García, Felipe; Romero, Jorge del; Benito, José Miguel; Alba, Verónica; Herrero, Pol; Rull, Anna; Domínguez-Molina, Beatriz; Martínez-Madrid, Onofre; Martín-Pena, Luisa; Pulido, Federico; Leon, Agathe; Rodríguez, Carmen ; Rallón, Norma; Peraire, Joaquim; Viladés, Consuelo; Leal, Manuel; Vidal, Francesc; Ruiz-Mateos, Ezequiel
Elite controllers
Loss of control
Proteomic profile
Issue Date15-Mar-2019
PublisherOxford University Press
CitationJournal of Infectious Diseases 219(6): 867-876 (2019)
Abstract[Background] Elite controllers (ECs) spontaneously control plasma human immunodeficiency virus type 1 (HIV-1) RNA without antiretroviral therapy. However, 25% lose virological control over time. The aim of this work was to study the proteomic profile that preceded this loss of virological control to identify potential biomarkers.
[Methods] Plasma samples from ECs who spontaneously lost virological control (transient controllers [TCs]), at 2 years and 1 year before the loss of control, were compared with a control group of ECs who persistently maintained virological control during the same follow-up period (persistent controllers [PCs]). Comparative plasma shotgun proteomics was performed with tandem mass tag (TMT) isobaric tag labeling and nanoflow liquid chromatography coupled to Orbitrap mass spectrometry.
[Results] Eighteen proteins exhibited differences comparing PC and preloss TC timepoints. These proteins were involved in proinflammatory mechanisms, and some of them play a role in HIV-1 replication and pathogenesis and interact with structural viral proteins. Coagulation factor XI, α-1-antichymotrypsin, ficolin-2, 14-3-3 protein, and galectin-3-binding protein were considered potential biomarkers.
[Conclusions] The proteomic signature associated with the spontaneous loss of virological control was characterized by higher levels of inflammation, transendothelial migration, and coagulation. Galectin-3 binding protein could be considered as potential biomarker for the prediction of virological progression and as therapeutic target in ECs.
Publisher version (URL)https://doi.org/10.1093/infdis/jiy599
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