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Title

19-epi-Okadaic Acid, a Novel Protein Phosphatase Inhibitor with Enhanced Selectivity

AuthorsCruz, Patricia G.; Hernández Daranas, Antonio ; Fernández, José J.; Norte, Manuel
KeywordsPeptides and proteins
Molecules
Inhibitors
Conformation
Noncovalent interactions
Issue Date14-Jul-2007
PublisherAmerican Chemical Society
CitationOrganic Letters 9(16): 3045–3048 (2007)
AbstractA new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, and important differences were found when compared with the lead compound okadaic acid. The new metabolite showed nanomolar activities, and its selectivity for PP2A versus PP1 surpasses that shown by okadaic acid 10-fold, making it one of the most selective inhibitors of this class.
Publisher version (URL)https://doi.org/10.1021/ol071099i
URIhttp://hdl.handle.net/10261/213360
DOIhttp://dx.doi.org/10.1021/ol071099i
ISSN1523-7060
E-ISSN1523-7052
Appears in Collections:(IPNA) Artículos
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