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Title

Enhancement of Antiproliferative Activity by Molecular Simplification of Catalpol

AuthorsGarcía, Celina; León, Leticia G; Pungitore, Carlos R.; Ríos-Luci, Carla; Hernández Daranas, Antonio ; Montero, Juan Carlos ; Pandiella, Atanasio ; Tonn, Carlos E.; Martín, Víctor S.; Padrón, José M.
KeywordsAntitumor agents
Catalpol
Cell cycle
Molecular simplification
Structure elucidation
Issue Date1-Apr-2010
PublisherElsevier
CitationBioorganic and Medicinal Chemistry 18(7): 2515-2523 (2010)
AbstractTwo iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed α-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38–1.86 μM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining.
Publisher version (URL)https://doi.org/10.1016/j.bmc.2010.02.044
URIhttp://hdl.handle.net/10261/213312
DOIhttp://dx.doi.org/10.1016/j.bmc.2010.02.044
ISSN0968-0896
E-ISSN1464-3391
Appears in Collections:(IBMCC) Artículos
(IPNA) Artículos
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