Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/213312
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Enhancement of Antiproliferative Activity by Molecular Simplification of Catalpol |
Autor: | García, Celina; León, Leticia G; Pungitore, Carlos R.; Ríos-Luci, Carla; Hernández Daranas, Antonio CSIC ORCID ; Montero, Juan Carlos CSIC ORCID; Pandiella, Atanasio CSIC ORCID CVN ; Tonn, Carlos E.; Martín, Víctor S. CSIC ORCID; Padrón, José M. | Palabras clave: | Antitumor agents Catalpol Cell cycle Molecular simplification Structure elucidation |
Fecha de publicación: | 1-abr-2010 | Editor: | Elsevier | Citación: | Bioorganic and Medicinal Chemistry 18(7): 2515-2523 (2010) | Resumen: | Two iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed α-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38–1.86 μM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining. | Versión del editor: | https://doi.org/10.1016/j.bmc.2010.02.044 | URI: | http://hdl.handle.net/10261/213312 | DOI: | 10.1016/j.bmc.2010.02.044 | ISSN: | 0968-0896 | E-ISSN: | 1464-3391 |
Aparece en las colecciones: | (IPNA) Artículos (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | Artículo principal | 16,34 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
21
checked on 08-abr-2024
WEB OF SCIENCETM
Citations
20
checked on 23-feb-2024
Page view(s)
165
checked on 23-abr-2024
Download(s)
31
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons