English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/213304
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Corozalic Acid: A Key Okadaic Acid Biosynthetic Precursor with Phosphatase Inhibition Activity

AuthorsNapolitano, José G.; Norte, Manuel; Fernández, José J.; Hernández Daranas, Antonio
KeywordsBiosynthesis
Enzyme inhibitors
Molecular modeling
Natural products
Okadaic acid
Issue Date11-Oct-2010
PublisherWiley-VCH
CitationChemistry - a European Journal 16(38): 11576-11579 (2010)
AbstractToxin precursors : Corozalic acid, a new Ser/Thr protein phosphatase 1 and 2A inhibitor that turned out to be a key metabolic intermediate, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. Detailed spectroscopic analysis and extensive computational calculations revealed its structure and conformational behavior. In addition, a comprehensive picture of the interactions of corozalic acid with PP1 and PP2A is proposed (see figure) on the basis of ab initio, docking and molecular dynamics calculations.
Publisher version (URL)https://doi.org/10.1002/chem.201001327
URIhttp://hdl.handle.net/10261/213304
DOIhttp://dx.doi.org/10.1002/chem.201001327
ISSN0947-6539
E-ISSN1521-3765
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdfArtículo principal16,34 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.