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Title

New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

AuthorsCen Pacheco, Francisco; Villa-Pulgarín, Janny A.; Mollinedo, Faustino ; Norte, Manuel; Fernández, José J.; Hernández Daranas, Antonio
KeywordsLaurencia viridis
Squalene
Polyethers
Cytotoxic activity
Issue Date7-Nov-2011
PublisherMolecular Diversity Preservation International
CitationMarine Drugs 9(11): 2220-2235 (2011)
AbstractThe red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)-dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
Publisher version (URL)https://doi.org/10.3390/md9112220
URIhttp://hdl.handle.net/10261/213287
DOI10.3390/md9112220
ISSN1660-3397
E-ISSN1660-3397
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