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Belizentrin, a Highly Bioactive Macrocycle from the Dinoflagellate Prorocentrum belizeanum

AuthorsDomínguez, Humberto J.; Napolitano, José G.; Fernández-Sánchez, M. Teresa; Cabrera-García, David; Novelli, Antonello; Norte, Manuel; Fernández, José J.; Hernández Daranas, Antonio
KeywordsChemical structure
Carbene compounds
Molecular structure
Mathematical methods
Issue Date15-Aug-2014
PublisherAmerican Chemical Society
CitationOrganic Letters 16(17): 4546–4549 (2014)
AbstractBelizentrin (1), a novel 25-membered polyketide-derived macrocycle, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. This metabolite is the first member of an unprecedented class of polyunsaturated and polyhydroxylated macrolactams. The structure of 1 was primarily determined by NMR and computational methods. Pharmacological assays with cerebellar cells showed that 1 produces important changes in neuronal network integrity at nanomolar concentrations.
Publisher version (URL)https://doi.org/10.1021/ol502102f
Appears in Collections:(IPNA) Artículos
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