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A perspective on microneedle-based drug delivery and diagnostics in paediatrics

AuthorsPires, Liliana R.Vinayakumar, KB; Turos, María; Miguel, Verónica ; Gaspar, Joao
Medical devices
Issue Date15-Nov-2019
CitationJournal of Personalized Medicine 9: 49 (2019)
AbstractMicroneedles (MNs) have been extensively explored in the literature as a means to deliver drugs in the skin, surpassing the stratum corneum permeability barrier. MNs are potentially easy to produce and may allow the self-administration of drugs without causing pain or bleeding. More recently, MNs have been investigated to collect/assess the interstitial fluid in order to monitor or detect specific biomarkers. The integration of these two concepts in closed-loop devices holds the promise of automated and minimally invasive disease detection/monitoring and therapy. These assure low invasiveness and, importantly, open a window of opportunity for the application of population-specific and personalised therapies
Publisher version (URL)http://dx.doi.org/10.3390/jpm9040049
Identifiersdoi: 10.3390/jpm9040049
issn: 2075-4426
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