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dc.contributor.authorRodríguez-Villodres, Ángeles_ES
dc.contributor.authorBonnin, Rémy A.es_ES
dc.contributor.authorOrtiz de la Rosa, José Manueles_ES
dc.contributor.authorÁlvarez-Marín, Rocíoes_ES
dc.contributor.authorNaas, Thierryes_ES
dc.contributor.authorAznar, Javieres_ES
dc.contributor.authorPachón, Jerónimoes_ES
dc.contributor.authorLepe, José A.es_ES
dc.contributor.authorSmani, Youneses_ES
dc.date.accessioned2020-06-02T13:15:12Z-
dc.date.available2020-06-02T13:15:12Z-
dc.date.issued2019-12-02-
dc.identifier.citationJournal of Clinical Medicine 8(12): 2118 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/213049-
dc.description.abstractEscherichia coli is the most frequent Gram-negative bacilli involved in intra-abdominal infections. However, despite high mortality rates associated with biliary tract infections due to E. coli, there is no study focusing on this pathogen. In this study, we have characterized a group of 15 E. coli isolates obtained from 12 patients with biliary tract infections. Demographic and clinical data of the patients were recovered. Phylogeny, resistome, and virulome analysis through whole genome sequencing and biofilm formation were investigated. Among the 15 E. coli isolates, no predominant sequence type (ST) was identified, although 3 of them belonged to unknown STs (20%). Resistance to ampicillin, amoxicillin/clavulanic acid, cotrimoxazole, and quinolones was more present in these isolates; whereas, third and fourth generation cephalosporins, carbapenems, amikacin, tigecycline, and colistin were highly active. Moreover, high diversity of virulence factors has been found, with sfa, fimH, and gad the most frequently detected genes. Interestingly, 26.6% of the E. coli isolates were high biofilm-producers. Altogether, our data characterized for the first time E. coli isolates associated with biliary tract infections in terms of genomic relationship, resistome, and virulome.es_ES
dc.description.sponsorshipThis work was supported by the Miguel Servet Tipo I Project grant, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades (CP15/00132), and by Plan Nacional de I+D+i 2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (RD16/0016/0009), cofinanced by the European Development Regional Fund “A Way to Achieve Europe,” Operative Program Intelligent Growth 2014-2020. This study was supported by the Assistance Publique – Hôpitaux de Paris (AP-HP), the University Paris-Sud, the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT) supported by a grant from the French National Research Agency (ANR-10-LABX-33). Y.S. is supported by the Subprograma Miguel Servet Tipo I, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spain (CP15/00132). A.R.V. is supported by the Subprograma Río Hortega, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spain (CM18/00122). R.A.M. is supported by the Subprograma Juan Rodés, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spain (JR17/00025).es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institutees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectEscherichia colies_ES
dc.subjectBiliary tract infectiones_ES
dc.subjectVirulomees_ES
dc.subjectResistomees_ES
dc.subjectBiofilmes_ES
dc.titlePhylogeny, Resistome, and Virulome of Escherichia coli Causing Biliary Tract Infectionses_ES
dc.typeartículoes_ES
dc.identifier.doi10.3390/jcm8122118-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jcm8122118es_ES
dc.identifier.e-issn2077-0383-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderRed Española de Investigación en Patología Infecciosaes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderUniversité Paris-Sudes_ES
dc.contributor.funderHôpitaux de Parises_ES
dc.contributor.funderAgence Nationale de la Recherche (France)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001665es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007486es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
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