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A case-control analysis of the impact of venous thromboembolic disease on quality of life of patients with cancer: Quality of life in cancer (Qca) study

AuthorsMarin-Barrera, Lucia; Muñoz-Martín, A. J.; Rios-Herranz, Eduardo; García-Escobar, Ignacio; Beato, Carmen; Font, Carme; Oncala-Sibajas, Estefania; Revuelta-Rodríguez, Alfonso; Areses, Maria Carmen; Rivas-Jiménez, Victor; Moreno-Santos, Maria Angeles; Ballaz-Quincoces, Aitor; López-Saez, Juan-Bosco; Gallego, Iria; Elías-Hernández, Teresa; Asensio-Cruz, María Isabel; Chasco-Eguilaz, Leyre; García-González, Gonzalo; Estévez-García, Purificación; Otero Candelera, Remedios; Lima-Alvarez, Jorge; Jara Palomares, Luis
Quality of life
Venous thromboembolism
Pulmonary embolism
Venous thrombosis
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationCancers 12(1): 75 (2020)
AbstractAlthough there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: −0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: −10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: −21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: −9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies.
Publisher version (URL)https://doi.org/10.3390/cancers12010075
Identifiersdoi: 10.3390/cancers12010075
e-issn: 2072-6694
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