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Sperm Differentiation: The Role of Trafficking of Proteins

AuthorsTeves, Maria E.; Roldán, Eduardo R. S. ; Krapf, Diego; Strauss III, Jerome F.; Bhagat, Virali; Sapao, Paulene
KeywordsProtein trafficking
Sperm differentiation
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationInternational Journal of Molecular Sciences 21(10): 3702 (2020)
AbstractSperm differentiation encompasses a complex sequence of morphological changes that takes place in the seminiferous epithelium. In this process, haploid round spermatids undergo substantial structural and functional alterations, resulting in highly polarized sperm. Hallmark changes during the differentiation process include the formation of new organelles, chromatin condensation and nuclear shaping, elimination of residual cytoplasm, and assembly of the sperm flagella. To achieve these transformations, spermatids have unique mechanisms for protein trafficking that operate in a coordinated fashion. Microtubules and filaments of actin are the main tracks used to facilitate the transport mechanisms, assisted by motor and non-motor proteins, for delivery of vesicular and non-vesicular cargos to specific sites. This review integrates recent findings regarding the role of protein trafficking in sperm differentiation. Although a complete characterization of the interactome of proteins involved in these temporal and spatial processes is not yet known, we propose a model based on the current literature as a framework for future investigations.
Description© 2020 by the authors.
Publisher version (URL)https://doi.org/10.3390/ijms21103702
Appears in Collections:(MNCN) Artículos
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