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Título

Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes

AutorPacheco-Quito, Edisson-Mauricio; Ruiz-Caro, Roberto; Rubio Alonso, Juan CSIC ORCID; Tamayo Hernando, Aitana CSIC ORCID CVN; Veiga, María Dolores
Palabras claveGenital herpes
Acyclovir controlled release
Mucoadhesive vaginal tablets
Marine polymers
Iota-carrageenan
Hydroxypropyl methylcellulose
Fecha de publicación11-may-2020
EditorMultidisciplinary Digital Publishing Institute
CitaciónMarine Drugs 18 (5): 249 (2020)
ResumenWomen are the most affected by genital herpes, which is one of the most common sexually transmitted infections, affecting more than 400 million people worldwide. The application of vaginal microbicides could provide a safe method of protection. Acyclovir is a safe and effective medication for vaginal administration, and numerous benefits have been observed in the treatment of primary or recurrent lesions due to genital herpes. Vaginal tablets based on a combination of the polymers iota-carrageenan and hydroxypropyl methylcellulose were developed for the controlled release of acyclovir. Swelling, mucoadhesion and drug release studies were carried out in simulated vaginal fluid. The tablets, containing a combination of iota-carrageenan and hydroxypropyl methylcellulose, have an adequate uptake of the medium that allows them to develop the precise consistency and volume of gel for the controlled release of acyclovir. Its high mucoadhesive capacity also allows the formulation to remain in the vaginal area long enough to ensure the complete release of acyclovir. These promising formulations for the prevention of genital herpes deserve further evaluation.
Versión del editorhttps://doi.org/10.3390/md18050249
URIhttp://hdl.handle.net/10261/212514
DOI10.3390/md18050249
Identificadoresdoi: 10.3390/md18050249
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