Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/212502
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Rodríguez-Martín, Noelia M. | - |
dc.contributor.author | Montserrat-de la Paz, Sergio | - |
dc.contributor.author | Toscano-Sánchez, Rocío | - |
dc.contributor.author | Grao‐Cruces, Elena | - |
dc.contributor.author | Villanueva, Álvaro | - |
dc.contributor.author | Pedroche, Justo | - |
dc.contributor.author | Millán, Francisco | - |
dc.contributor.author | Millán-Linares, María del Carmen | - |
dc.date.accessioned | 2020-05-28T14:08:35Z | - |
dc.date.available | 2020-05-28T14:08:35Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Biomolecules 10(5): 803 (2020) | - |
dc.identifier.uri | http://hdl.handle.net/10261/212502 | - |
dc.description | © 2020 by the authors. | - |
dc.description.abstract | Hemp seeds have a wide variety of chemical compounds which present biological activity. Specifically, the focus on proteins and bioactive peptides are increasing as alternative sources of nutraceutical uses. In the literature, hemp protein products (HPPs) have reported antioxidant and anti-inflammatory properties. This study aimed to determine the inflammation-related modulatory effects of HPPs on lipopolysaccharide (LPS)-activated primary human monocytes. CD14+ cells were immunomagnetically isolated from buffy coats and the anti-inflammatory activity of hemp protein isolate (HPI) and hydrolysates (HPHs) was evaluated on LPS-stimulated human primary monocytes. The specific markers of inflammation, polarization, and chemoattraction were measured by RT-qPCR and ELISA assays. Our results showed that HPPs decreased the pro-inflammatory mediators (TNF-α, IL-1β, and IL-6) and increased the anti-inflammatory mediators (IL-10 and IL-4). In addition, M1 polarization marker gene expression (CCR7 and iNOS) was downregulated by HPPs and, M2 polarization marker gene expression (CD200R and MRC1) was upregulated. Finally, the mRNA expression of chemotaxis genes (CCR2 and CCL2) was downregulated by HPPs. In conclusion, this study suggests that HPPs may improve chronic inflammatory states and promote regenerative processes by reprogramming monocytes toward M2 polarization phenotype. | - |
dc.description.sponsorship | This research was funded by CYTED Ciencia y Tecnología para el Desarrollo, grant number CYTED-2019 119RT0567. | - |
dc.language.iso | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Hemp seed | - |
dc.subject | Protein hydrolysates | - |
dc.subject | Peptides | - |
dc.title | Hemp (Cannabis sativa L.) Protein Hydrolysates Promote Anti-Inflammatory Response in Primary Human Monocytes | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/biom10050803 | - |
dc.description.peerreviewed | Peer reviewed | - |
dc.relation.publisherversion | https://doi.org/10.3390/biom10050803 | - |
dc.identifier.e-issn | 2218-273X | - |
dc.date.updated | 2020-05-28T14:08:35Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo | - |
dc.relation.csic | Sí | - |
dc.identifier.pmid | 32456009 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Hemp_Rodriguez_Art2020.pdf | 2,34 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
11
checked on 26-mar-2024
SCOPUSTM
Citations
37
checked on 11-abr-2024
WEB OF SCIENCETM
Citations
29
checked on 26-feb-2024
Page view(s)
142
checked on 18-abr-2024
Download(s)
106
checked on 18-abr-2024