English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/212501
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorPallàs, Mercè-
dc.contributor.authorVázquez, Santiago-
dc.contributor.authorSanfeliu, Coral-
dc.contributor.authorGaldeano, Carles-
dc.contributor.authorGriñán-Ferré, Christian-
dc.date.accessioned2020-05-28T14:08:31Z-
dc.date.available2020-05-28T14:08:31Z-
dc.date.issued2020-05-01-
dc.identifier.citationBiomolecules 10(5): 703 (2020)-
dc.identifier.issn2218-273X-
dc.identifier.urihttp://hdl.handle.net/10261/212501-
dc.description© 2020 by the authors.-
dc.description.abstractNeuroinflammation is a crucial process associated with the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Several pieces of evidence suggest an active role of lipid mediators, especially epoxy-fatty acids (EpFAs), in the genesis and control of neuroinflammation; 14,15-epoxyeicosatrienoic acid (14,15-EET) is one of the most commonly studied EpFAs, with anti-inflammatory properties. Soluble epoxide hydrolase (sEH) is implicated in the hydrolysis of 14,15-EET to its corresponding diol, which lacks anti-inflammatory properties. Preventing EET degradation thus increases its concentration in the brain through sEH inhibition, which represents a novel pharmacological approach to foster the reduction of neuroinflammation and by end neurodegeneration. Recently, it has been shown that sEH levels increase in brains of PD patients. Moreover, the pharmacological inhibition of the hydrolase domain of the enzyme or the use of sEH knockout mice reduced the deleterious effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. This paper overviews the knowledge of sEH and EETs in PD and the importance of blocking its hydrolytic activity, degrading EETs in PD physiopathology. We focus on imperative neuroinflammation participation in the neurodegenerative process in PD and the putative therapeutic role for sEH inhibitors. In this review, we also describe highlights in the general knowledge of the role of sEH in the central nervous system (CNS) and its participation in neurodegeneration. We conclude that sEH is one of the most promising therapeutic strategies for PD and other neurodegenerative diseases with chronic inflammation process, providing new insights into the crucial role of sEH in PD pathophysiology as well as a singular opportunity for drug development-
dc.description.sponsorshipThis study was supported by the Ministerio de Economía, Industria y Competitividad (Agencia Estatal de Investigación, AEI) and Fondo Europeo de Desarrollo Regional (MINECO-FEDER) (Projects SAF2017-82771-R, SAF2016-33307, RTI2018-096429-B-100). C.G.-F., S.V., C.S., and M.P. belong to 2017SGR106 (Generalitat de Catalunya).-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationMICIU/ICTI2017-2020/SAF2017-82771-R-
dc.relationSAF2017-82771-R/AEI/10.13039/501100011033-
dc.relationMINECO/ICTI2013-2016/SAF2016-33307-
dc.relation.isversionofPublisher’s version-
dc.rightsopenAccess-
dc.subjectEpoxyeicosatrienoic acids-
dc.subjectSoluble epoxide hydrolase-
dc.subjectParkinson’s disease-
dc.subjectNeuroinflammation-
dc.titleSoluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/biom10050703-
dc.description.peerreviewedPeer reviewed-
dc.relation.publisherversionhttps://doi.org/10.3390/biom10050703-
dc.identifier.e-issn2218-273X-
dc.date.updated2020-05-28T14:08:31Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderAgencia Estatal de Investigación (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderGeneralitat de Catalunya-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
Soluble_Pallas_Art2020.pdf2,77 MBAdobe PDFThumbnail
View/Open
Show simple item record
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.