English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/212474
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorRossi, Elisaes_ES
dc.contributor.authorBernabéu, Carmeloes_ES
dc.contributor.authorSmadja, David M.es_ES
dc.date.accessioned2020-05-28T13:19:02Z-
dc.date.available2020-05-28T13:19:02Z-
dc.date.issued2019-01-30-
dc.identifier.citationFrontiers in Medicine 6 (10) 1-8 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/212474-
dc.description8 p.-2 fig.es_ES
dc.description.abstractEndoglin (ENG) is a transmembrane glycoprotein expressed on endothelial cells that functions as a co-receptor for several ligands of the transforming growth factor beta(TGF-b) family. ENG is also a recognized marker of angiogenesis and mutations in the endoglin gene are responsible for Hereditary Hemorrhagic Telangiectasia (HHT) type 1, a vascular disease characterized by defective angiogenesis, arteriovenous malformations, telangiectasia, and epistaxis. In addition to its involvement in the TGF-b family signaling pathways, several lines of evidence suggest that the extracellular domain of ENG has a role in integrin-mediated cell adhesion via its RGD motif. Indeed, we have described a role for endothelial ENG in leukocyte trafficking and extravasation via its binding to leukocyte integrins.We have also found that ENG is involved in vasculogenic properties of endothelial progenitor cells known as endothelial colony forming cells (ECFCs).Moreover,the binding of endothelial ENG to platelet integrins regulate the resistance to shear during platelet-endotheliuminteractions under inflammatory conditions. Because of the need for more effective treatments in HHT and the involvement of ENG in angiogenesis, current studies are aimed at identifying novel biological functions of ENG which could serve as a therapeutic target. This review focuses on the interaction between ENG and integrins with the aim to better understand the role of this protein in blood vessel formation driven by progenitor and mature endothelial cells.es_ES
dc.description.sponsorshipDS wrote the manuscript and provided funding support.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectEndoglines_ES
dc.subjectEndothelial progenitorses_ES
dc.subjectEPCes_ES
dc.subjectECFCses_ES
dc.subjectHHT1es_ES
dc.subjectIntegrinses_ES
dc.subjectTGF-betaes_ES
dc.titleEndoglin as an adhesion molecule in mature and progenitor endothelial cells: a function beyond TGF-βes_ES
dc.typeartículoes_ES
dc.identifier.doi10.3389/fmed.2019.00010-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmed.2019.00010es_ES
dc.identifier.e-issn2296-858X-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidRossi, Elisa [0000-0002-0570-6104]es_ES
dc.contributor.orcidBernabéu, Carmelo 0000-0002-1563-6162es_ES
dc.contributor.orcidSmadja, David M. [0000-0001-7731-9202]es_ES
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
fmed_Rossi_2019.pdfArtículo principal900,31 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.