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Title

Tachykinins and Kisspeptins in the Regulation of Human Male Fertility

AuthorsBlasco, Víctor; Pinto, Francisco M.; González-Ravina, Cristina; Santamaría-López, Esther; Candenas, M. Luz ; Fernandez-Sanchez, M.
KeywordsTachykinin
Kisspeptin
Neurokinin
Male infertility
Assisted reproductive technology
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationJournal of Clinical Medicine 9: E113 (2020)
AbstractInfertility is a global disease affecting one out of six couples of reproductive age in the world, with a male factor involved in half the cases. There is still much to know about the regulation of human male fertility and thus we decided to focus on two peptide families that seem to play a key role in this function: tachykinins and kisspeptins. With this aim, we conducted an exhaustive review in order to describe the role of tachykinins and kisspeptins in human fertility and their possible implications in infertility etiopathogenesis. Many advances have been made to elucidate the roles of these two families in infertility, and multiple animal species have been studied, including humans. All of this knowledge could lead to new advances in male infertility diagnosis and treatment, but further research is needed to clarify all the implications of tachykinins and kisspeptins in fertility.
Publisher version (URL)http://dx.doi.org/10.3390/jcm9010113
URIhttp://hdl.handle.net/10261/212463
DOI10.3390/jcm9010113
Identifiersdoi: 10.3390/jcm9010113
issn: 2077-0383
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