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Title

Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines

AuthorsSalinas, L. M.; Balseiro, Ana ; Jirón, W.; Peralta, A.; Muñoz, D.; Fajardo, J.; Gayo, E.; Martínez, I. Z.; Riet-Correa, F.; Gardner, D. R.; García Marín, Juan Francisco
KeywordsGoat
Poisoning
Ipomoeatrifida
Ipomoeacarnea
Calystegines
Nicaragua
Issue Date2019
PublisherElsevier
CitationToxicon : official journal of the International Society on Toxinology 157: 8- 11 (2019)
AbstractA disease characterized by ataxia, tremors and nystagmus had been observed in goats in Nicaragua. The main histologic lesions were loss and neuronal vacuolation of Purkinje cells and Wallerian-like degeneration mainly in the cerebellum, suggesting a glycoprotein storage disease. Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of β-glucosidase and α-galactosidase activities.
Description4 páginas, 1 tabla, 1 figura.
Publisher version (URL)http://dx.doi.org/10.1016/j.toxicon.2018.11.291
URIhttp://hdl.handle.net/10261/212429
DOIhttp://dx.doi.org/10.1016/j.toxicon.2018.11.291
Identifiersdoi: 10.1016/j.toxicon.2018.11.291
issn: 0041-0101
Appears in Collections:(IGM) Artículos
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