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dc.contributor.authorFernández-Tornero, Carloses_ES
dc.contributor.authorBöttcher, Bettinaes_ES
dc.contributor.authorRashid, Umar J.es_ES
dc.contributor.authorMüller, Christoph W.es_ES
dc.date.accessioned2020-05-28T08:40:42Z-
dc.date.available2020-05-28T08:40:42Z-
dc.date.issued2011-09-01-
dc.identifier.citationRNA Biol 8 (5) 760–765 (2011)es_ES
dc.identifier.issn1547-6286-
dc.identifier.urihttp://hdl.handle.net/10261/212424-
dc.description6 p.-2 fig.es_ES
dc.description.abstractRecent electron cryomicroscopy reconstructions have provided new insights into the overall organization of yeast RNA polymerase (Pol) III, responsible for the synthesis of small, non-translated RNAs. The structure of the free Pol III enzyme at 10 Å resolution provides an accurate framework to better understand its overall architecture and the structural organization and functional role of two Pol III-specific subcomplexes. Cryo-EM structures of elongating Pol III bound to DNA/RNA scaffolds show the rearrangement of the Pol III-specific subcomplexes that enclose incoming DNA. In one reconstruction downstream DNA and newly transcribed RNA can be followed over considerably longer distances as in the crystal structure of elongating Pol II. The Pol III transcription machinery is increasingly recognized as a possible target for cancer therapy. The recent cryo-EM reconstructions contribute to the molecular understanding of Pol III transcription as a prerequisite for targeting its components.es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.rightsclosedAccesses_ES
dc.subjectTranscriptional regulationes_ES
dc.subjectRNA polymerase IIIes_ES
dc.subjectElectron cryomicroscopyes_ES
dc.subjectTranscription elongationes_ES
dc.subjectTranscription initiationes_ES
dc.subjectTFIIIBes_ES
dc.subjectMaf1es_ES
dc.titleAnalyzing RNA polymerase III by electron cryomicroscopyes_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.4161/rna.8.5.16021-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.4161/rna.8.5.16021es_ES
dc.identifier.e-issn1555-8584-
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidFernández-Tornero, Carlos [0000-0001-5097-731X]es_ES
dc.contributor.orcidBöttcher, Bettina [0000-0002-7962-4849]es_ES
dc.contributor.orcidMüller, Christoph W. [0000-0003-2176-8337]es_ES
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