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Title

Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group

AuthorsGonzález, Antonio G.; Hernández Silva, Margarita; Padrón, Juan I. ; León, Francisco ; Reyes, Eduardo; Álvarez-Mon, Melchor; Pivel, Juan P.; Quintana, José; Estévez, Francisco; Bermejo, Jaime
KeywordsLactones
Plastics
Apoptosis
Genetics
Biopolymers
Issue Date11-May-2002
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 45(12): 2358–2361 (2002)
AbstractThe biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.
Publisher version (URL)https://doi.org/10.1021/jm025518n
URIhttp://hdl.handle.net/10261/212313
DOIhttp://dx.doi.org/10.1021/jm025518n
ISSN0022-2623
E-ISSN1520-4804
Appears in Collections:(IPNA) Artículos
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