Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group

English español

Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/212313

Share/Impact:

Statistics	SHARE CORE Mendeley BASE	Share your Open Access Story
	See citations in Google Scholar
	Visualizar otros formatos: MARC \| Dublin Core \| RDF \| ORE \| MODS \| METS \| DIDL \| DATACITE
	Exportar a otros formatos:

Title:	Synthesis and Antiproliferative Activity of a New Compound Containing an α-Methylene-γ-Lactone Group
Authors:	González, Antonio G.; Hernández Silva, Margarita; Padrón, Juan I. ; León, Francisco ; Reyes, Eduardo; Álvarez-Mon, Melchor; Pivel, Juan P.; Quintana, José; Estévez, Francisco; Bermejo, Jaime
Keywords:	Lactones Plastics Apoptosis Genetics Biopolymers
Issue Date:	11-May-2002
Publisher:	American Chemical Society
Citation:	Journal of Medicinal Chemistry 45(12): 2358–2361 (2002)
Abstract:	The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.
Publisher version (URL):	https://doi.org/10.1021/jm025518n
URI:	http://hdl.handle.net/10261/212313
DOI:	http://dx.doi.org/10.1021/jm025518n
ISSN:	0022-2623
E-ISSN:	1520-4804
Appears in Collections:	(IPNA) Artículos

File	Description	Size	Format
accesoRestringido.pdf	Artículo principal	16,34 kB	Adobe PDF	View/Open