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Title

New Lanostanoids from the Fungus Ganoderma concinna

AuthorsGonzález, Antonio G.; León, Francisco ; Rivera, Augusto; Padrón, Juan I. ; González-Plata, Javier; Zuluaga, Juan C.; Quintana, José; Estévez, Francisco; Bermejo, Jaime
KeywordsMorphology
Apoptosis
Carbon
Chemical structure
Carbonyls
Issue Date3-Mar-2002
PublisherAmerican Society of Pharmacognosy
American Chemical Society
CitationJournal of Natural Products 65(3): 417–421 (2002)
AbstractThree new compounds, 5α-lanosta-7,9(11),24-triene-3β-hydroxy-26-al (1), 5α-lanosta-7,9(11),24-triene-15α-26-dihydroxy-3-one (2), and 8α,9α-epoxy-4,4,14α-trimethyl-3,7,11,15,20-pentaoxo-5α-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds 1 and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.
Publisher version (URL)https://doi.org/10.1021/np010143e
URIhttp://hdl.handle.net/10261/212309
DOIhttp://dx.doi.org/10.1021/np010143e
ISSN0163-3864
E-ISSN1520-6025
Appears in Collections:(IPNA) Artículos
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