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Title

Steroidal Saponins from the Bark of Dracaena draco and Their Cytotoxic Activities

AuthorsGonzález, Antonio G.; Hernández, Juan C. ; León, Francisco ; Padrón, Juan I. ; Estévez, Francisco; Quintana, José; Bermejo, Jaime
KeywordsCarbohydrates
Apoptosis
Genetics
Alkyls
Toxicity
Issue Date29-May-2003
PublisherAmerican Society of Pharmacognosy
CitationJournal of Natural Products 66(6): 793–798 (2003)
AbstractFrom the stem bark of Dracaena draco, three new compounds, namely, draconins A−C (1−3), were isolated, along with 17 known compounds. The structures of the new compounds isolated were elucidated on the basis of spectroscopic data interpretation. Several of the isolated compounds showed potent cytotoxic activities measured on the human leukemia cell line HL-60 (IC50's from 2.0 to 9.7 μM at 72 h). The mechanism by which compounds 1 and 2 display their cytostatic properties is through induction of cell death by apoptosis, as evaluated by fluorescence microscopy and DNA fragmentation.
Publisher version (URL)https://doi.org/10.1021/np020517j
URIhttp://hdl.handle.net/10261/212300
DOIhttp://dx.doi.org/10.1021/np020517j
ISSN0163-3864
E-ISSN1520-6025
Appears in Collections:(IPNA) Artículos
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