Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/212288
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia |
Autor: | Pérez-Nadales, Elena; Gutiérrez-Gutiérrez, Belén CSIC ORCID; Natera, Alejandra M.; Abdala, Edson; Reina Magalhães, Maira; Mularoni, Alessandra; Monaco, Francesco; Camera Pierrotti, Ligia; Pinheiro Freire, Maristela; Iyer, Ranganathan N.; Mehta Steinke, Seema; Grazia Calvi, Elisa; Tumbarello, Mario; Falcone, Marco; Fernández-Ruiz, Mario; Costa-Mateo, Jose M.; Rana, Meenakshi M.; Mara Varejao Strabelli, Tania; Paul, Mical; Fariñas, María del Carmen; Trindade Clemente, Wanessa; Roilides, Emmanuel; Muñoz García, Patricia; Dewispelaere, Laurent; Loeches, Belén; Lowman, Warren; Hock Tan, Ban; Escudero-Sánchez, Rosa; Bodro, Marta; Grossi, Paolo Antonio; Soldani, Fabio; Gunseren, Filiz; Nestorova, Nina; Pascual, Álvaro CSIC ORCID; Martínez-Martínez, Luis; Aguado, José María; Aguado, José María; Torre-Cisneros, Julián | Palabras clave: | Antibiotic drug resistance Clinical research/practice Infection and infectious agents - bacterial Infectious diseases Organ transplantation in general |
Fecha de publicación: | jun-2020 | Editor: | John Wiley & Sons | Citación: | American Journal of Transplantation 20(6): 1629-1641 (2020) | Resumen: | Treatment of carbapenemase‐producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase‐producing Enterobacterales bloodstream infections. A multinational, retrospective (2004‐2016) cohort study (INCREMENT‐SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30‐day all‐cause mortality. The INCREMENT‐SOT‐CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT‐CPE mortality score ≥8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT‐CPE score ≥8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76‐0.88) and classified patients into 3 strata: 0‐7 (low mortality), 8‐11 (high mortality), and 12‐17 (very‐high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very‐high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13‐7.06, P = .03) and high (HR 9.93, 95% CI 2.08‐47.40, P = .004) mortality risk strata. A score‐based algorithm is provided for therapy guidance. | Versión del editor: | https://doi.org/10.1111/ajt.15769 | URI: | http://hdl.handle.net/10261/212288 | DOI: | 10.1111/ajt.15769 | Identificadores: | doi: 10.1111/ajt.15769 e-issn: 1600-6143 issn: 1600-6135 |
Aparece en las colecciones: | (IBIS) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
21
checked on 13-mar-2024
WEB OF SCIENCETM
Citations
18
checked on 25-feb-2024
Page view(s)
687
checked on 19-mar-2024
Download(s)
60
checked on 19-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.