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β′-Hydroxy-α,β-unsaturated ketones: A new pharmacophore for the design of anticancer drugs

AuthorsPadrón, José M.; Miranda, Pedro O. ; Padrón, Juan I. ; Martín, Víctor S.
KeywordsUnsaturated ketones
Solid tumors
Drug design
Structure–activity relationships
Anticancer drugs
Issue Date15-Apr-2006
CitationBioorganic and Medicinal Chemistry Letters 16(8): 2266-2269 (2006)
AbstractA series of β′-hydroxy-α,β-unsaturated ketones were prepared by means of an iron(III) catalyzed domino process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573, and WiDr. The results showed that β′-hydroxy-α,β-unsaturated ketones were more potent than α,β-unsaturated ketones. The best activity profiles were obtained for the derivatives bearing cyclic or branched substituents on the side chains.
Publisher version (URL)https://doi.org/10.1016/j.bmcl.2006.01.023
Appears in Collections:(IPNA) Artículos
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