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Title

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

AuthorsCrichton, Siobhan; Belfrage, Eric; Collins, Intira Jeanne; Doerholt, Katja; Judd, Ali; Le Coeur, Sophie; Spoulou, Vana; Goodall, Ruth; Scherpbier, Henriette; Smit, Colette; Goetghebuer, Tessa; Hillebregt, M.; de Boer, C. G.; Jurriaans, S.; Back, N. K. T.; Gamell, Anna; Zaaijer, H. L.; Wisse, A.; Strik-Albers, R.; Popielska, Jolanta; Berkhout, B.; Verduyn-Lunel, F.; Cornelissen, M. T. E.; Schinkel, C. J.; Wolthers, K. C.; Fraaij, P. L. A.; Fernandez Mc Phee, Carolina; van Rossum, A. M. C.; Fortuny, Claudia; Gibb, Diana M.; Vermont, C. L.; Apilanez, Miren; Okhonskaia, Liubov; van der Knaap, L. C.; Rahamat-Langendoen, J.; Witte, E. C.; Visser, E. G.; Stelma, F. F.; Scholvinck, E. H.; de Groot-de Jonge, H.; Niesters, H. G. M.; Romano, Amelia; van Leer-Buter, C. C.; Angulo, Raquel; Ruggeri, Maurizio; Alvarez, Susana; Knoester, M.; Bont, L. J.; Guerrero, Carmelo; Badillo, Katie; Geelen, S. P. M.; Woudstra, T.; Wolfs, T. F. W.; Nauta, N.; Neth, Olaf; Noguera-Julián, Antoni; Lodewijk, C.; Bergsma, D.; Grivell, S.; Meijering, R.; Raethke, M.; Roa, Miguel Angel; Collado, Pilar; Rutkens, T.; Lo Vecchio, Andrea; Falcon, Lola; de Groot, L.; van den Akker, M.; Lucas, E.; Thorne, Claire; Bakker, Y.; van der Meer, R.; Munjishvili, L.; Paling, E.; Luisa Navarro, Maria; Peeck, B.; Pas, S. D.; Perez, Amparo; Ree, C.; Regtop, R.; Faldella, Giacomo; Jourdain, Gonzague; Ruijs, Y.; Pokorska-Spiewak, Maria; Martinez, Jorge; van de Sande, L.; Oldakowska, Agnieszka; Terol, Pedro; Zawadka, Konrad; Coupland, Urszula; Doroba, Malgorzata; Reiss, P.; Baldi, Francesco; Voronin, Evgeny; Boucher, C. A. B.; Galli, Luisa; Miloenko, Milana; Labutina, Svetlana; Consolini, Rita; Rampon, Osvalda; Marczynska, Magdalena; Soler-Palacin, Pere; Antoinette Frick, Maria; Perez-Hoyos, Santiago; Badolato, Raffaele; Mur, Antonio; Piqueras, Ana I.; Mellado, Maria Jose; Lopez, Nuria; Segarra, Inmaculada; Mendez, Maria; Mayol, Lluis; Vallmanya, Teresa; Giaquinto, Carlo; Dona, Daniele; Calavia, Olga; Montagnani, Carlotta; Schuurman, R.; García, Lourdes; Coll, María T.; Genovese, Orazio; Escosa-García, Luis; Breton, Rafael; Pineda, Valenti; Garcia Hortelano, Milagros; Sainz, Talia; Gonzalez-Tome, Maria I.; Rojo, Pablo; Veenenberg, L.; Blazquez, Daniel; Dodi, Icilio; Luis Santos, Juan; Prieto, Luis; Guillen, Sara; Koopmans, M. P. G.; Kuekou, Hyppolite Tchidjou; Saavedra-Lozano, Jesús; Pocheville, Itziar; Santa Ansone; Santos, Mar; Venturini, Elisabetta; Garrote, Elisa; Moreno-Pérez, David; Colino, Elena; Gomez Sirvent, Jorge; Garzon, Monica; Maccabruni, Anna; van Kampen, J. J. A.; Roman, Vicente; Schoorl, M.; Montesdeoca, Abián; Mateo, Mercedes; van Sighem, A., I; Lendinez, Francisco; Muñoz, Maria José; Grande, Ana; Jose Romero, Francisco; Wensing, A. M. J.; Perez, Carlos; Henriet, S. S., V; de Tejada, Begona Martinez; Lillo, Miguel; Bezemer, M.; de Jong, A.; Losada, Begoña; Gavilán, César; Bernardi, Stefania; Herranz, Mercedes; Jareno, Enrique; Montesinos, Elena; Dapena, Marta; Alvarez, Cristina; Jiménez de Ory, Santiago; El Berkaoui, A.; Gloria Andres, Ana; Rius, Neus; Zaheri, S.; Marugan, Victor; Ochoa, Carlos; Schnorr, P.; Wit, F. W. M. N.; Alfayate, Santiago; Decker, Luc; Menasalvas, Ana Isabel; Geerlinks, J.; Miguel, E. de; van de Flier, M.; Lisi, Catiuscia; Ene, Luminita; Hainaut, Marc; Van der Kelen, Evelyne; Delforge, Marc; Bezemer, D. O.; Tuijn, E.; de Martino, Maurizio; Koops, J.; Muñoz-Fernandez, M. Angeles; Tovo, Pier Angelo; Patrizia, Osimani; Di Biagio, Antonio; van Aerde, K.; Larovere, Domenico; Taramasso, Lucia; Giacomet, Vania; Erba, Paola; Esposito, Susanna; Couceiro, José; Lipreri, Rita; van der Vliet, S.; Salvini, Filippo; Tagliabue, Claudia; Rovira, Nuria; Tuk, B.; Cellini, Monica; Olmeo, Paolina; Smit, C.; Bruzzese, Eugenia; Kruijne, E.; Cristiano, Letizia; Mazza, Antonio; Gabiano, Clara; Garazzino, Silvia; Tomás Ramos, José; Dueñas, Joaquin; Pellegatta, Antonio; Bustillo, Matilde; Pajkrt, D.; Scherpbier, H. J.; Beceiro, Jose; Weijsenfeld, A. M.; Ruiz, Beatriz
KeywordsEurope
Growth
Height
HIV
Perinatal
Puberty
Thailand
Issue Date2019
PublisherLippincott Williams & Wilkins
CitationAIDS 33(12): 1897–1910 (2019)
Abstract[Objective]: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. [Design]: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. [Methods]: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1–10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. [Results]: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and −1.2 (IQR: −2.3 to −0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20–0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21–1.78) years later in those starting with HAZ less than −3 compared with HAZ at least −1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than −1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least −1, there was no association with age. Girls and boys who initiated ART with HAZ at least −1 maintained a similar height to the WHO reference mean. [Conclusion]: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least −1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age.
DescriptionThe European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group.
Publisher version (URL)https://doi.org/10.1097/QAD.0000000000002294
URIhttp://hdl.handle.net/10261/212274
DOIhttp://dx.doi.org/10.1097/QAD.0000000000002294
Identifiersdoi: 10.1097/QAD.0000000000002294
issn: 0269-9370
e-issn: 1473-5571
Appears in Collections:(IBIS) Artículos
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