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dc.contributor.authorMiranda, Pedro O.es_ES
dc.contributor.authorPadrón, José M.es_ES
dc.contributor.authorPadrón, Juan I.es_ES
dc.contributor.authorVillar, Jesúses_ES
dc.contributor.authorMartín, Víctor S.es_ES
dc.date.accessioned2020-05-27T06:51:41Z-
dc.date.available2020-05-27T06:51:41Z-
dc.date.issued2006-03-01-
dc.identifier.citationChemMedChem 1(3): 323-329 (2006)es_ES
dc.identifier.issn860-7179-
dc.identifier.urihttp://hdl.handle.net/10261/212267-
dc.description.abstractA series of functionalized tetrahydropyran and dihydropyran derivatives was synthesized by means of a Prins‐type cyclization between unsaturated alcohols and several aldehydes. An unprecedented dimer bearing two 4‐chloro‐5,6‐dihydro‐2H ‐pyran scaffolds was obtained in high yield. A panel of three representative human solid tumor cells from diverse origin was used to assess the cytotoxicity of the compounds. Overall, the results show the relevance of the chlorovinyl group in the biological activity, and 2‐alkyl‐4‐chloro‐5,6‐dihydro‐2H ‐pyrans represent interesting leads for further chemical modifications and biological studies.es_ES
dc.language.isoenges_ES
dc.publisherWiley-VCHes_ES
dc.relation.isversionofPostprintes_ES
dc.rightsclosedAccesses_ES
dc.subjectAntitumor agentses_ES
dc.subjectIron(III ) chloridees_ES
dc.subjectOrganohalogen drugses_ES
dc.subjectPrins reactiones_ES
dc.subjectStructure–activity relationshipes_ES
dc.titlePrins‐Type Synthesis and SAR Study of Cytotoxic Alkyl Chloro Dihydropyranses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/cmdc.200500057-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/cmdc.200500057es_ES
dc.identifier.e-issn1860-7187-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderMinisterio de Educación y Cultura (España)es_ES
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)es_ES
dc.contributor.funderGobierno de Canariases_ES
dc.relation.csicNoes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006280es_ES
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