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One-pot synthesis and SAR study of cis-2,6-dialkyl-4-chloro-tetrahydropyrans

AuthorsMiranda, Pedro O. ; León, Leticia G.; Martín, Víctor S.; Padrón, Juan I. ; Padrón, José M.
KeywordsMarine drugs
Halogenated tetrahydropyrans
Solid tumors
Drug design
Structure–activity relationship
Issue Date15-Jun-2006
CitationBioorganic and Medicinal Chemistry Letters 16(12): 3135-3138 (2006)
AbstractA series of cis-2,6-dialkyl-4-chloro-tetrahydropyrans were prepared by means of an iron(III)-catalyzed process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573, and WiDr. The results show that the presence of bulky substituents favors the Prins cyclization leading to new products with better activity profile against all cell lines tested.
Publisher version (URL)https://doi.org/10.1016/j.bmcl.2006.03.064
Appears in Collections:(IPNA) Artículos
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