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Antiproliferative activity of 4-chloro-5,6-dihydro-2H-pyrans. Part 2: Enhancement of drug cytotoxicity

AuthorsLeón, Leticia G.; Miranda, Pedro O. ; Martín, Víctor S.; Padrón, Juan I. ; Padrón, José M.
KeywordsAntitumor agents
Iron(III) chloride
Organohalogen drugs
Prins reaction
Structure–activity relationships
Issue Date1-Jun-2007
CitationBioorganic and Medicinal Chemistry Letters 17(11): 3087-3090 (2007)
AbstractThe Prins reaction was the basis to synthesize functionalized alkyl chlorodihydropyran derivatives. The inexpensive, stable, and environmentally friendly FeCl3 promotes the cyclization. The method represents an efficient and regioselective manner to obtain in a single step chlorovinyl–TMS oxacycles. The in vitro antiproliferative activities of the compounds were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show an enhancement in the cytotoxicity exhibited by the new analogs when compared to their parental compounds.
Publisher version (URL)https://doi.org/10.1016/j.bmcl.2007.03.045
Appears in Collections:(IPNA) Artículos
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