English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/212245
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorLeón, Leticia G.es_ES
dc.contributor.authorMiranda, Pedro O.es_ES
dc.contributor.authorMartín, Víctor S.es_ES
dc.contributor.authorPadrón, Juan I.es_ES
dc.contributor.authorPadrón, José M.es_ES
dc.date.accessioned2020-05-26T15:36:18Z-
dc.date.available2020-05-26T15:36:18Z-
dc.date.issued2007-06-01-
dc.identifier.citationBioorganic and Medicinal Chemistry Letters 17(11): 3087-3090 (2007)es_ES
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10261/212245-
dc.description.abstractThe Prins reaction was the basis to synthesize functionalized alkyl chlorodihydropyran derivatives. The inexpensive, stable, and environmentally friendly FeCl3 promotes the cyclization. The method represents an efficient and regioselective manner to obtain in a single step chlorovinyl–TMS oxacycles. The in vitro antiproliferative activities of the compounds were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show an enhancement in the cytotoxicity exhibited by the new analogs when compared to their parental compounds.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rightsclosedAccesses_ES
dc.subjectAntitumor agentses_ES
dc.subjectIron(III) chloridees_ES
dc.subjectOrganohalogen drugses_ES
dc.subjectPrins reactiones_ES
dc.subjectStructure–activity relationshipses_ES
dc.titleAntiproliferative activity of 4-chloro-5,6-dihydro-2H-pyrans. Part 2: Enhancement of drug cytotoxicityes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.bmcl.2007.03.045-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.bmcl.2007.03.045es_ES
dc.identifier.e-issn1464-3405-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España)es_ES
dc.contributor.funderGobierno de Canariases_ES
dc.relation.csicNoes_ES
oprm.item.hasRevisionno ko 0 false*
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdfArtículo principal16,34 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.