English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/212245
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Antiproliferative activity of 4-chloro-5,6-dihydro-2H-pyrans. Part 2: Enhancement of drug cytotoxicity

AuthorsLeón, Leticia G.; Miranda, Pedro O. ; Martín, Víctor S.; Padrón, Juan I. ; Padrón, José M.
KeywordsAntitumor agents
Iron(III) chloride
Organohalogen drugs
Prins reaction
Structure–activity relationships
Issue Date1-Jun-2007
PublisherElsevier
CitationBioorganic and Medicinal Chemistry Letters 17(11): 3087-3090 (2007)
AbstractThe Prins reaction was the basis to synthesize functionalized alkyl chlorodihydropyran derivatives. The inexpensive, stable, and environmentally friendly FeCl3 promotes the cyclization. The method represents an efficient and regioselective manner to obtain in a single step chlorovinyl–TMS oxacycles. The in vitro antiproliferative activities of the compounds were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show an enhancement in the cytotoxicity exhibited by the new analogs when compared to their parental compounds.
Publisher version (URL)https://doi.org/10.1016/j.bmcl.2007.03.045
URIhttp://hdl.handle.net/10261/212245
DOI10.1016/j.bmcl.2007.03.045
ISSN0960-894X
E-ISSN1464-3405
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdfArtículo principal16,34 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.