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http://hdl.handle.net/10261/212235
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | León, Leticia G. | es_ES |
dc.contributor.author | Carballo, Rubén M. | es_ES |
dc.contributor.author | Vega-Hernández, María C. | es_ES |
dc.contributor.author | Miranda, Pedro O. | es_ES |
dc.contributor.author | Martín, Víctor S. | es_ES |
dc.contributor.author | Padrón, Juan I. | es_ES |
dc.contributor.author | Padrón, José M. | es_ES |
dc.date.accessioned | 2020-05-26T14:55:17Z | - |
dc.date.available | 2020-05-26T14:55:17Z | - |
dc.date.issued | 2008-11-06 | - |
dc.identifier.citation | ChemMedChem 3(11): 1740-1747 (2008) | es_ES |
dc.identifier.issn | 1860-7179 | - |
dc.identifier.uri | http://hdl.handle.net/10261/212235 | - |
dc.description.abstract | Novel antiproliferative β′‐acyloxy‐α,β ‐unsaturated ketones were obtained by means of an iron(III)‐catalyzed multicomponent domino process (ABB′ 3CR). The most active derivatives displayed GI50 values in the range of 0.5–3.9 μ M against a panel of representative human solid tumor cell lines: A2780, SW1573, HBL‐100, T‐47D and WiDr. Analysis of cells following 24 h exposure to these drugs showed cell cycle arrest in the S and G2/M phase, in a dose‐dependent manner. Our data indicate that the β ′‐acyloxy‐α,β ‐unsaturated ketones cause permanent damage to the cells and induce apoptosis. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Structure–activity relationships | es_ES |
dc.subject | Antitumor agents | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Cell cycle | es_ES |
dc.subject | Iron(III) chloride | es_ES |
dc.title | β′‐Hydroxy‐α,β‐unsaturated ketones: A new pharmacophore for the design of anticancer drugs. Part 2. | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/cmdc.200800212 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/cmdc.200800212 | es_ES |
dc.identifier.e-issn | 1860-7187 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Educación y Cultura (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Gobierno de Canarias | es_ES |
dc.contributor.funder | Fundación Canaria de Investigación y Salud | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100007650 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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