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dc.contributor.authorLeón, Leticia G.es_ES
dc.contributor.authorCarballo, Rubén M.es_ES
dc.contributor.authorVega-Hernández, María C.es_ES
dc.contributor.authorMiranda, Pedro O.es_ES
dc.contributor.authorMartín, Víctor S.es_ES
dc.contributor.authorPadrón, Juan I.es_ES
dc.contributor.authorPadrón, José M.es_ES
dc.date.accessioned2020-05-26T14:55:17Z-
dc.date.available2020-05-26T14:55:17Z-
dc.date.issued2008-11-06-
dc.identifier.citationChemMedChem 3(11): 1740-1747 (2008)es_ES
dc.identifier.issn1860-7179-
dc.identifier.urihttp://hdl.handle.net/10261/212235-
dc.description.abstractNovel antiproliferative β′‐acyloxy‐α,β ‐unsaturated ketones were obtained by means of an iron(III)‐catalyzed multicomponent domino process (ABB′ 3CR). The most active derivatives displayed GI50 values in the range of 0.5–3.9 μ M against a panel of representative human solid tumor cell lines: A2780, SW1573, HBL‐100, T‐47D and WiDr. Analysis of cells following 24 h exposure to these drugs showed cell cycle arrest in the S and G2/M phase, in a dose‐dependent manner. Our data indicate that the β ′‐acyloxy‐α,β ‐unsaturated ketones cause permanent damage to the cells and induce apoptosis.es_ES
dc.language.isoenges_ES
dc.publisherWiley-VCHes_ES
dc.relation.isversionofPostprintes_ES
dc.rightsclosedAccesses_ES
dc.subjectStructure–activity relationshipses_ES
dc.subjectAntitumor agentses_ES
dc.subjectApoptosises_ES
dc.subjectCell cyclees_ES
dc.subjectIron(III) chloridees_ES
dc.titleβ′‐Hydroxy‐α,β‐unsaturated ketones: A new pharmacophore for the design of anticancer drugs. Part 2.es_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/cmdc.200800212-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/cmdc.200800212es_ES
dc.identifier.e-issn1860-7187-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderMinisterio de Educación y Cultura (España)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderGobierno de Canariases_ES
dc.contributor.funderFundación Canaria de Investigación y Saludes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100007650es_ES
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