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A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor

AuthorsPons, Guillem; Riba, Daniel; Casasampere, Mireia; Izquierdo, Eduardo; Abad, José Luis ; Fabriàs, Gemma ; Rodríguez Ortega, Pilar G.; Montejo, Manuel; López González, Juan J.; Casas, Josefina ; Delgado Cirilo, Antonio
Enzyme substrates
Issue Date17-Jan-2020
PublisherAmerican Chemical Society
CitationJournal of Organic Chemistry 85 (2): 419-429 (2020)
AbstractThe synthesis of a series of vinylated analogues of sphingosine-1-phosphate together with their unambiguous configurational assignment by VCD methods is reported. Among them, compound RBM10-8 can irreversibly inhibit human sphingosine-1-phosphate lyase (hS1PL) while behaving also as an enzyme substrate. These findings, together with the postulated mechanism for S1PL activity, reinforce the role of RBM10-8 as a new mechanism-based hS1PL inhibitor. Copyright © 2019 American Chemical Society.
Publisher version (URL)10.1021/acs.joc.9b02420
Appears in Collections:(IQAC) Artículos
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