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Title

A "trojan horse" into the early intestinal microbiome development: the intrapartum antimicrobial prophylaxis

AuthorsArboleya, Silvia ; Saturio López, Silvia; Valle, B.; Nogacka, Alicja; Milani, Christian; Mantecón, L.; Fernández, Nuria; Suárez, Marta ; Solís, Gonzalo; Ventura, Marco; González de los Reyes-Gavilán, Clara ; Gueimonde Fernández, Miguel
Issue Date31-Oct-2019
CitationWoMPBI (2019)
AbstractIntrapartum antimicrobial prophylaxis (IAP) is an important protocol to reduce mortality by invasive Group B streptococcal (GBS) disease. In the 80s was demonstrated that administering IAP during labour to women at risk for transmitting GBS prevented invasive disease and infections of newborns decreased by 80%. However, we are still starting to understand the effect of IAP on the gut microbiome establishment. The correct gut microbiota colonization at the beginning of life is a key event for the foundation of early and future health and is affected by different perinatal factors. It is known that antibiotics highly affect the microbiota and that early postnatal exposure increases risk of later diseases. Moreover, the most frequent cause of contact with antibiotics during the perinatal period is the use of IAP, present in over 30% of deliveries. We have analysed the impact of IAP on the gut microbial colonization in premature (n=69) and full-term babies (n=41) and, how IAP affects the levels of antibiotic resistance genes, enzymes and transporters involved on the antibiotic resistance process. We have shown that IAP delays the colonization of beneficial bacteria. In addition, we have observed higher levels of antibiotic resistance genes, enzymes and transporters involved on the antibiotic resistances on babies whose mothers were subjected to IAP. Our results confirm an impact of the IAP treatment on the correct establishment of the intestinal microbiota and highlight the need of new intervention strategies development based on microbial modulation, with aim to minimize the IAP effects in early life.
DescriptionTrabajo presentado en el World of Microbiome: Pregnancy, Birth & Infancy (WoMPBI), celebrado en Milán (Italia), del 31 de octubre al 2 de noviembre de 2019
URIhttp://hdl.handle.net/10261/212038
Appears in Collections:(IPLA) Comunicaciones congresos
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