Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/21184
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Low potential ocular irritation of arginine-based gemini surfactants and their mixtures with nonionic and zwitterionic surfactants

AutorMitjans, Montserrat; Martínez, Verónica; Clapés Saborit, Pere CSIC ORCID ; Pérez, Lourdes CSIC ORCID ; Infante, María Rosa CSIC ; Vinardell, M. Pilar CSIC ORCID
Palabras claveHemolysis
Arginine-based surfactants
Red blood cell
Lipoamino acids
Ocular irritation
Fecha de publicaciónjun-2003
EditorSpringer Nature
CitaciónPharmaceutical Research 20(10): 1697-1701 (2003)
Resumen[Purpose] The aim of this study was to find new biocompatible surfactants and mixtures with low ocular irritant action for application in pharmaceutical formulations and to establish a relationship between their structure and their potential ocular irritant activity.
[Methods] An alternative method to the Draize in vivo test, based on the adverse effects of surfactants on the cytoplasmic membrane of red blood cell, was used to evaluate the potential ocular irritation of the surfactants.
[Results] It was found that the hemolytic activity of arginine-based gemini surfactants increased with the aliphatic alkyl chain lengths of the hydrophobic tail. The addition of the surfactant with an alkyl chain length of 10 carbon atoms to cocoamidopropilbetaina (TB), decylglucoside (APG), and Nagr-lauroyl-arginine ethyl ester (LAE) increases the hemolytic activity moderately for the mixtures with TB and LAE (1.1- and 1.5-fold, respectively) and strongly for APG (fivefold).
[Conclusions] The new arginine-based gemini surfactants constitute a suitable alternative to commercial surfactants because of their natural origins, which make them biocompatible and renewable products. Based on their hemolytic activity as an alternative to the Draize test, these new arginine-based gemini surfactants and their mixtures can be classified as mild irritants. This fact constitutes an advantage, especially for pharmaceutical and cosmetic applications.
Descripción5 pages, 3 figures, 1 table.-- PMID: 14620528 [PubMed].-- Available online Nov 1, 2004.
Versión del editorhttp://dx.doi.org/10.1023/A:1026164123938
URIhttp://hdl.handle.net/10261/21184
DOI10.1023/A:1026164123938
ISSN0724-8741
E-ISSN1573-904X
Aparece en las colecciones: (IQAC) Artículos

Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

37
checked on 27-mar-2024

WEB OF SCIENCETM
Citations

34
checked on 18-feb-2024

Page view(s)

358
checked on 29-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.