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Tropolactones A-D, four new meroterpenoids from a marine-derived fungus of the genus Aspergillus

AuthorsCueto, Mercedes ; MacMillan, John B.; Jensen, Paul R.; Fenical, William
Marine-derived fungus
Issue DateAug-2006
CitationPhytochemistry 67(16): 1826-1831 (2006)
AbstractFour cytotoxic meroterpenoids, tropolactones A–D, were isolated from the whole broth extract of a marine-derived fungus of the genus Aspergillus. The structures of the meroterpenoids were established through a variety of two-dimensional NMR techniques. The absolute configuration of tropolactone A was determined using the modified Mosher method. Tropolactones A–C contain an interesting substituted 2,4,6-cycloheptatriene (tropone) ring, which presumably arises through an oxidative ring expansion from tropolactone D. Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 μg/mL.
Publisher version (URL)https://doi.org/10.1016/j.phytochem.2006.01.008
Identifiersdoi: 10.1016/j.phytochem.2006.01.008
issn: 0031-9422
e-issn: 1873-3700
Appears in Collections:(IPNA) Artículos
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