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Title

A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure

AuthorsAntonis, Adraan F.G.; Bruschke, Christianne J.; Rueda, Paloma; Maranga, Luis; Casal, J. Ignacio ; Vela, Carmen; Hilgers, L. A.; Belt, P. B.; Weerdmeester, K.; Carrondo, Manuel José Teixeira; Langeveld, Jan Pm. M.
KeywordsPorcine parvovirus
Virus-like particles
Vaccine
Recombinant
Issue Date29-Jun-2006
PublisherElsevier
CitationVaccine 24 (26) 5481-90 (2006)
AbstractA novel vaccine against porcine parvovirus (PPV), composed of recombinant virus-like particles (PPV-VLPs) produced with the baculovirus expression vector system (BEVS) at industrial scale, was tested for its immunogenicity and protective potency. A formulation of submicrogram amounts of PPV-VLPs in a water-in-mineral oil adjuvant evoked high serum antibody titres in both guinea pigs, used as reference model, and target species, pigs. A single immunisation with 0.7microg of this antigen yielded complete foetal protection against PPV infection after challenge with a virulent strain of this virus. Furthermore, also in the presence of mild adjuvants the protective action of these PPV-VLPs is excellent. This recombinant subunit vaccine overcomes some of the drawbacks of classical PPV vaccines.
Description10 p.-4 fig.-1 tab.
Publisher version (URL)https://doi.org/10.1016/j.vaccine.2006.03.089
URIhttp://hdl.handle.net/10261/211611
DOIhttp://dx.doi.org/10.1016/j.vaccine.2006.03.089
ISSN0264-410X
Appears in Collections:(CIB) Artículos
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