English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/211397
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases

AuthorsGarcía Cuesta, Eva M.; Santiago, César A.; Vallejo Díaz, Jesús; Juarranz, Yasmina; Rodríguez Frade, José Miguel; Mellado, Mario
KeywordsACKR3
CXCL12 chemokine
CXCR4 = chemokine receptor 4
autoimmunity
chemokines/chemokine receptors
inflammation.
Issue DateAug-2019
PublisherFrontiers Media
CitationFrontiers in endocrinology 10:585 (2019)
AbstractChemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise regulation of cell positioning. CXCR4 is one of the most studied chemokine receptors and is involved in many functions beyond leukocyte recruitment. During embryogenesis, it plays essential roles in vascular development, hematopoiesis, cardiogenesis, and nervous system organization. It has been also implicated in tumor progression and autoimmune diseases and, together with CD4, is one of the co-receptors used by the HIV-1 virus to infect immune cells. In contrast to other chemokine receptors that are characterized by ligand promiscuity, CXCR4 has a unique ligand-stromal cell-derived factor-1 (SDF1, CXCL12). However, this ligand also binds ACKR3, an atypical chemokine receptor that modulates CXCR4 functions and is overexpressed in multiple cancer types. The CXCL12/CXCR4/ACKR3 axis constitutes a potential therapeutic target for a wide variety of inflammatory diseases, not only by interfering with cell migration but also by modulating immune responses. Thus far, only one antagonist directed against the ligand-binding site of CXCR4, AMD3100, has demonstrated clinical relevance. Here, we review the role of this ligand and its receptors in different autoimmune diseases.
Publisher version (URL)https://doi.org/10.3389/fendo.2019.00585
URIhttp://hdl.handle.net/10261/211397
DOI10.3389/fendo.2019.00585.
E-ISSN1664-2392
Appears in Collections:(CNB) Artículos
Files in This Item:
File Description SizeFormat 
MELLADO, Mario - Front. Endocrinol. 2019.pdfArtículo pincipal1,01 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.