English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/211385
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator

AuthorsPereiro, Patricia ; Librán-Pérez, Marta; Figueras Huerta, Antonio ; Novoa, Beatriz
KeywordsGdf15
Zebrafish
Sepsis
Tolerance
LPS
Metabolism
Issue Date2020
PublisherElsevier
CitationDevelopmental and Comparative Immunology 109: 103698 (2020)
AbstractGDF15 is frequently detected in patients suffering from various diseases, especially those associated with pro-inflammatory processes and/or metabolic disorders. Accordingly, sepsis, whose major complications are related to metabolic alterations and systemic inflammation, significantly increases the secretion of GDF15. Indeed, this cytokine could be considered a marker of sepsis severity. However, until the last several years, the involvement of GDF15 in these disorders had not been widely characterized. In mice, GDF15 was recently described as a pivotal inducer of sepsis tolerance by mediating metabolic alterations that reduce tissue damage. In this work we describe a zebrafish gdf15 gene. We found that gdf15 follows an expression pattern similar to that observed in mammals, being highly expressed in the liver and kidney and induced after pro-inflammatory stimuli. Moreover, larvae overexpressing gdf15 were more resistant to bacterial and viral challenges without affecting the pathogen load. Consequently, Gdf15 also protected zebrafish larvae against LPS-induced mortality. As in mice, zebrafish Gdf15 seems to induce sepsis tolerance by altering the metabolic parameters of the individuals
Description14 pages, 9 figures, 1 table
Publisher version (URL)https://doi.org/10.1016/j.dci.2020.103698
URIhttp://hdl.handle.net/10261/211385
DOI10.1016/j.dci.2020.103698
ISSN0145-305X
E-ISSN1879-0089
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
Conserved_function_zebrafish_2020.pdf Embargoed until August 1, 20211,62 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.