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Título: | Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator |
Autor: | Pereiro, Patricia CSIC ORCID; Librán-Pérez, Marta CSIC; Figueras Huerta, Antonio CSIC ORCID ; Novoa, Beatriz CSIC ORCID | Palabras clave: | Gdf15 Zebrafish Sepsis Tolerance LPS Metabolism |
Fecha de publicación: | 2020 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 109: 103698 (2020) | Resumen: | GDF15 is frequently detected in patients suffering from various diseases, especially those associated with pro-inflammatory processes and/or metabolic disorders. Accordingly, sepsis, whose major complications are related to metabolic alterations and systemic inflammation, significantly increases the secretion of GDF15. Indeed, this cytokine could be considered a marker of sepsis severity. However, until the last several years, the involvement of GDF15 in these disorders had not been widely characterized. In mice, GDF15 was recently described as a pivotal inducer of sepsis tolerance by mediating metabolic alterations that reduce tissue damage. In this work we describe a zebrafish gdf15 gene. We found that gdf15 follows an expression pattern similar to that observed in mammals, being highly expressed in the liver and kidney and induced after pro-inflammatory stimuli. Moreover, larvae overexpressing gdf15 were more resistant to bacterial and viral challenges without affecting the pathogen load. Consequently, Gdf15 also protected zebrafish larvae against LPS-induced mortality. As in mice, zebrafish Gdf15 seems to induce sepsis tolerance by altering the metabolic parameters of the individuals | Descripción: | 14 pages, 9 figures, 1 table | Versión del editor: | https://doi.org/10.1016/j.dci.2020.103698 | URI: | http://hdl.handle.net/10261/211385 | DOI: | 10.1016/j.dci.2020.103698 | ISSN: | 0145-305X | E-ISSN: | 1879-0089 |
Aparece en las colecciones: | (IIM) Artículos |
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Conserved_function_zebrafish_2020.pdf | 1,62 MB | Adobe PDF | Visualizar/Abrir |
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