English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/211363
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Nanoparticles of 4,7-dichloro-2-quinolinemethylacrylate-based copolymers and their cytotoxic effect on Human breast carcinoma cells

AuthorsValle, Hernán; Palao-Suay, Raquel; Aguilar, María Rosa ; San Román, Julio ; Becerra, José; Rivas, Bernabé; Viswanathan Mangalaraja, Ramalinga
KeywordsBiomedical applications
Radical polymerization
Issue Date2019
PublisherJohn Wiley & Sons
CitationJournal of Applied Polymer Science 136: 47545 (2019)
AbstractIn this article, an improved synthesis strategy of the potent anticancer compound 4,7-dichloro-2-quinolinemethanol(QM) and its acrylate ester 4,7-dichloro-2-quinolinemethylacrylate (AQM) are described. AQM is copolymerized using free-radicalpolymerization with N-vinyl-2-pyrrolidone (VP) and the copolymers obtained from different molar ratios of monomers are subjected tonanoprecipitation to produce suspensions of nanoparticles (NPs) in phosphate buffered saline (PBS). The smallest and stable NPs areprepared with the AQM-VP copolymers 45:55 and 40:60 (118.9 and 128.7 nm in diameter, respectively) at 1 mg mL¿1, and along withAQM and QM, are evaluated for their cytotoxic activity on MDA-MB-453 breast carcinoma cells using MTT bioassay. AQM and QMare highly cytotoxic (IC50: 19 and 41 ¿ M, respectively); however, the NPs are not cytotoxic in the range of the assayed concentrations.These results contribute to the search for new polymeric NPs with potential application as QM delivery systems for the treatment ofcancer or other diseases treatable with QM.
Publisher version (URL)http://dx.doi.org/10.1002/app.4754
Identifiersdoi: 10.1002/app.4754
issn: 0021-8995
issn: 1097-4628
Appears in Collections:(ICTP) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.