Please use this identifier to cite or link to this item:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

AuthorsUrdinguio, Rocío G. CSIC ORCID; López, Virginia CSIC ORCID; Bayón, Gustavo F.; Díaz de la Guardia, Rafael; Sierra, Marta I.; García-Toraño, Estela; Pérez, Raúl F. CSIC ORCID; García, María G.; Carella, Antonella; Pruneda, Patricia C.; Prieto, Cristina; Dmitrijeva, Marija; Santamarina-Ojeda, Pablo; Belmonte, Thalia; Mangas, Cristina; Diaconu, Elena; Ferrero, Cecilia; Tejedor, Juan Ramón CSIC ORCID ; Fernández-Morera, Juan L.; Bravo, Cristina; Bueno, Clara; Sanjuan-Pla, Alejandra; Rodríguez López, Ramón María; Suárez-Álvarez, Beatriz; López-Larrea, Carlos; Bernal, Teresa; Colado, Enrique; Balbín, Milagros; García-Suarez, Olivia; Chiara, María-Dolores; Sáenz-de-Santa-María, Inés; Rodríguez, Francisco; Pando-Sandoval, Ana; Rodrigo, Luis; Santos, Laura; Salas, Ana; Vallejo-Díaz, Jesús; Carrera, Ana C.; Rico, Daniel; Hernández-López, Inmaculada; Vayá, Amparo; Ricart, José M.; Seto, Edward; Sima-Teruel, Núria; Vaquero, Alejandro CSIC ORCID; Valledor, Luis; Cañal, María Jesús; Pisano, David; Graña-Castro, Osvaldo; Thomas, Tim; Voss, Anne K.; Menéndez, Pablo; Villar-Garea, Ana; Deutzmann, Rainer; Fernández, Agustín F. CSIC ORCID; Fraga, Mario F. CSIC ORCID
Issue Date2019
PublisherOxford University Press
CitationNucleic Acids Research 47(10): 5016-5037 (2019)
AbstractHistone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death.
Publisher version (URL)
Identifiersdoi: 10.1093/nar/gkz195
e-issn: 1362-4962
issn: 0305-1048
Appears in Collections:(CNB) Artículos
(CINN) Artículos

Files in This Item:
File Description SizeFormat
chromacompart.pdf5,36 MBAdobe PDFThumbnail
Show full item record
Review this work

PubMed Central

checked on Jan 10, 2023


checked on Jan 24, 2023


checked on Jan 24, 2023

Page view(s)

checked on Jan 27, 2023


checked on Jan 27, 2023

Google ScholarTM




Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.