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Title: | Eubiotic effect of buckwheat D-fagomine in healthy rats |
Authors: | Hereu, Mercè; Ramos-Romero, Sara; García-González, N.; Amézqueta, Susana; Torres, Josep Lluís ![]() |
Issue Date: | 2018 |
Publisher: | Elsevier BV |
Citation: | Journal of Functional Foods 50: 120-126 (2018) |
Abstract: | Diversity and balance of gut microorganisms is fundamental for health throughout life. The aim of this study is to explore the possible eubiotic effect of the buckwheat iminosugar D-fagomine (0.096% w/w in standard feed) in growing healthy Wistar Kyoto rats. Feed and energy intake, residual energy in feces, and body weight gain were independent of D-fagomine supplementation throughout the intervention (24 weeks). The populations of significant bacterial subgroups and species were determined in fecal and cecal DNA by quantitative real-time PCR. D-Fagomine increased the Bacteroidetes:Firmicutes ratio and partially counteracted the loss of Lactobacilliales and Bifidobacteriales over time. The supplementation reduced the levels of excreted short-chain fatty acids (SCFAs) as determined by gas chromatography. This paper provides preliminary evidence that D-fagomine has the capacity to promote microbial functional diversity by increasing the Bacteroidetes:Firmicutes ratio and to mitigate the age-related reduction in populations of the putatively beneficial Lactobacilliales and Bifidobacteriales. |
Publisher version (URL): | http://dx.doi.org/10.1016/j.jff.2018.09.018 |
URI: | http://hdl.handle.net/10261/211207 |
DOI: | 10.1016/j.jff.2018.09.018 |
Identifiers: | doi: 10.1016/j.jff.2018.09.018 issn: 1756-4646 |
Appears in Collections: | (IQAC) Artículos |
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Eubiotic effect of buckwheat 1 D-fagomine in healthy rats.pdf | 314,09 kB | Adobe PDF | ![]() View/Open |
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