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Eubiotic effect of buckwheat D-fagomine in healthy rats

AuthorsHereu, Mercè; Ramos-Romero, Sara; García-González, N.; Amézqueta, Susana; Torres, Josep Lluís
Issue Date2018
PublisherElsevier BV
CitationJournal of Functional Foods 50: 120-126 (2018)
AbstractDiversity and balance of gut microorganisms is fundamental for health throughout life. The aim of this study is to explore the possible eubiotic effect of the buckwheat iminosugar D-fagomine (0.096% w/w in standard feed) in growing healthy Wistar Kyoto rats. Feed and energy intake, residual energy in feces, and body weight gain were independent of D-fagomine supplementation throughout the intervention (24 weeks). The populations of significant bacterial subgroups and species were determined in fecal and cecal DNA by quantitative real-time PCR. D-Fagomine increased the Bacteroidetes:Firmicutes ratio and partially counteracted the loss of Lactobacilliales and Bifidobacteriales over time. The supplementation reduced the levels of excreted short-chain fatty acids (SCFAs) as determined by gas chromatography. This paper provides preliminary evidence that D-fagomine has the capacity to promote microbial functional diversity by increasing the Bacteroidetes:Firmicutes ratio and to mitigate the age-related reduction in populations of the putatively beneficial Lactobacilliales and Bifidobacteriales.
Publisher version (URL)http://dx.doi.org/10.1016/j.jff.2018.09.018
Identifiersdoi: 10.1016/j.jff.2018.09.018
issn: 1756-4646
Appears in Collections:(IQAC) Artículos
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