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Title

Fate of d-Fagomine after Oral Administration to Rats

AuthorsAmézqueta, Susana; Ramos-Romero, Sara; Martínez-Guimet, Carolina; Moreno, Aalbert; Hereu, Mercè; Torres, Josep Lluís
Issue Date2017
CitationJournal of agricultural and food chemistry 65: 4414- 4420 (2017)
Abstractd-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and reducing the postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered d-fagomine in rats and compares outcomes with the fate of 1-deoxynojirimycin. d-Fagomine and 1-deoxynojirimycin show similar absorption and excretion kinetics. d-Fagomine is partly absorbed (41-84%, dose of 2 mg/kg of body weight) and excreted in urine within 8 h, while the non-absorbed fraction is cleared in feces within 24 h. d-Fagomine is partially methylated (about 10% in urine and 3% in feces). The concentration of d-fagomine in urine from 1 to 6 h after administration is higher than 10 mg/L, the concentration that inhibits adhesion of Escherichia coli. Orally administered d-fagomine is partially absorbed and then rapidly excreted in urine, where it reaches a concentration that may be protective against urinary tract infections.
Publisher version (URL)http://dx.doi.org/10.1021/acs.jafc.7b01026
URIhttp://hdl.handle.net/10261/211205
Identifiersdoi: 10.1021/acs.jafc.7b01026
issn: 1520-5118
Appears in Collections:(IQAC) Artículos
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