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Oleuropein and its Peracetylated Derivative Negatively Regulate Osteoclastogenesis by Controlling the Expression of Genes Involved in Osteoclast Differentiation and Function

AuthorsRosillo, María Ángeles; Montserrat-de la Paz, Sergio ; Abia, Rocío ; López-Castejón, Mª Luisa; Millán-Linares, María del Carmen ; Alarcón de la Lastra, C.; Fernández-Bolaños, José G.; Muriana, Francisco J. G.
Issue Date2020
PublisherRoyal Society of Chemistry (UK)
CitationFood and Function: (2020)
AbstractDuring chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) have well established effects on gene networks that stimulate osteoclastogenesis, which is the culprit of several bone diseases. In this study, we investigated the anti-osteoclastogenic effects in vitro of oleuropein (OL) and its peracetylated derivative (Per-OL) by exploring the expression level of key hub genes involved in fate decision and lineage commitment, differentiation, and function of human blood monocyte-derived osteoclasts. Monocytes were purified from peripheral blood mononuclear cells of healthy individuals using commercial antibodies coated with magnetic beads and treated with M-CSF/RANKL in the presence or absence of OL or Per-OL (25 and 50 μM) for 6 days. We demonstrated that OL and especially Per-OL impair transcriptional gene circuits able to support osteoclastogenesis from human blood monocytes. Our results indicate that OL and notably Per-OL are promising candidates to control osteoclastogenesis.
Description11 Páginas.-- 6 Figuras.-- 1 Tabla
Publisher version (URL)http://dx.doi.org/10.1039/D0FO00433B
Identifiersdoi: 10.1039/D0FO00433B
issn: 2042-6496
e-issn: 2042-650X
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