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Title

Developmental expression of H3.3A variant histone mRNA in mouse

AuthorsLópez-Fernández, Luis A.; López-Alañón, Dulce M.; Castañeda, Vianney; Krimer, Dora B. ; Del Mazo, Jesús
KeywordsH3.3A-cap
Variant histone
Gene expression
Issue DateOct-1997
PublisherUniversidad del País Vasco
CitationInt J Dev Biol 41(5) 699-703 (1997)
AbstractCloning and characterization of H3.3A variant histone expression has recently been reported to be associated with meiotic development in mouse testis and ovary. Using Northern analysis and in situ hybridization, the pattern of H3.3A expression was studied during the development of different tissues. In addition to the differential expression detected in male and female meiosis, H3.3A was found to be highly expressed in preantral follicles of adult ovaries and in the basal regions of seminiferous epithelium corresponding to spermatogonia. Different patterns of expression were observed in somatic tissues, which also differed with respect to the developmental stage of the tissue. The lowest expression was detected in adult skeletal muscle. High expressions were found in foetal liver and spinal cord. These different expressions might reflect a possible function of H3.3A in cell differentiation as detected in MEL cells.
Description5 p.-8 fig.
Publisher version (URL)http://www.ijdb.ehu.es/web/paper.php?doi=9415489
URIhttp://hdl.handle.net/10261/210536
ISSN0214-6282
E-ISSN1696-3547
Appears in Collections:(CIB) Artículos
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